Fig. 7: BSA-Man@Mn2+-Ft@Lap nanoassembly promotes DC maturation and cross-priming in vivo to enhance T cell infiltration and effector function.
From: A protein-based cGAS-STING nanoagonist enhances T cell-mediated anti-tumor immune responses
a–e Flow cytometric analysis on the expression levels of DC maturation (CD80/CD86), M1/M2 macrophage ratio (F4/80/CD86+ and F4/80/CD206+), and T cell activation state (CD4/CD8, CD8a/IFN-γ) in 4T1 tumor tissues after treatment with (I) control, (II) BSA-Man-Ft, (III) BSA-Man-Ft@Lap, (IV) BSA-Man@Mn2+-Ft, and (V) BSA-Man@Mn2+-Ft@Lap in vivo. f–i Serum levels of IFN-β, IFN-γ, TNF-α, and IL-6 in 4T1 tumor-bearing mice after different treatments. j Immunofluorescence analysis of the intratumoral infiltration of CD4/CD8 T cells in 4T1 tumor-bearing mice after different treatments. Flow cytometry and immunofluorescence experiments in panels a–e and j were repeated three times independently with similar results. Data are presented as mean values ± SEM (n = 6 mice for panels f–i). Statistical analysis for panels f–i was carried out via one-way ANOVA method. * Indicates significance at p < 0.05, ** indicates significance at p < 0.01, *** indicates significance at p < 0.001. Source data are provided as a Source data file.
