Table 1 Morphological and functional assessments of the left ventricles by echocardiography in scrambled control and Tmem65 KD mice

From: Tmem65 is critical for the structure and function of the intercalated discs in mouse hearts

 

Scrambled shRNA

Tmem65 shRNA

 

(n = 6)

(n = 6)

AWes (mm)

1.36 ± 0.06

0.6 ± 0.10**

ESD (mm)

2.31 ± 0.16

4.30 ± 0.14**

PWes (mm)

1.13 ± 0.08

0.69 ± 0.08**

AWed (mm)

0.85 ± 0.14

0.53 ± 0.09**

EDD (mm)

3.78 ± 0.14

4.54 ± 0.13**

PWed (mm)

0.71 ± 0.01

0.62 ± 0.07*

EF (%)

76.75 ± 3.05

14.83 ± 3.92**

FS (%)

39.10 ± 2.69

5.33 ± 1.50**

Stroke volume (µl)

47.64 ± 5.25

14.58 ± 1.72**

Heart rate (beats/min)

419.33 ± 29.36

455.83 ± 12.25

Cardiac output (ml/min)

19.27 ± 1.46

6.63 ± 0.52**

  1. Echocardiography was performed on 6 female mice in each group 6 weeks post viral injection.
  2. AWes anterior wall thickness at end-systole, ESD end-systolic diameter of left ventricular chamber, AWed anterior wall thickness at end-diastole, EDD end-diastole diameter of left ventricular chamber, PWed posterior wall thickness at end-diastole, PWes posterior wall thickness at end-systole, EF ejection fraction, FS fraction shortening, mm millimeter, µl microliter, ml milliliter, min minute.
  3. *p  <  0.05, **p < 0.01.
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