Fig. 7: Reduced expression of IL12rb1 in Irf1-deficient intestinal ILC3s. | Nature Communications

Fig. 7: Reduced expression of IL12rb1 in Irf1-deficient intestinal ILC3s.

From: Interferon regulatory factor 1 (IRF-1) promotes intestinal group 3 innate lymphoid responses during Citrobacter rodentium infection

Fig. 7: Reduced expression of IL12rb1 in Irf1-deficient intestinal ILC3s.The alt text for this image may have been generated using AI.

Irf1+/– and Irf1–/– mice were infected with C. rodentium and were sacrificed eight days post infection. a Quantification of Il12rb1 (Irf1+/–: n = 13, Irf1–/–: n = 10), Il12rb2 (Irf1+/–: n = 17, Irf1–/–: n = 12) and Il23r (Irf1+/–: n = 12, Irf1–/–: n = 10) transcripts in total RNA of distal colon tissue samples by specific qRT-PCR. b, c Flow cytometric analysis of IL-12Rβ1 (n = 5/group) and IL-23R (Irf1+/–: n = 4, Irf1–/–: n = 3)-expressing ILC3s (lin-Thy1.2+RORγt+ cells). Data is expressed as mean ± SEM. Exact p– values defined by two-tailed Mann-Whitney U test are provided in the plots. Source data are provided as a Source data file.

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