Fig. 1: EphA2 promotes disease progression during disseminated candidiasis.
From: IL-23 signaling prevents ferroptosis-driven renal immunopathology during candidiasis
a Survival of wild-type and Dectin-1–/–(Clec7a–/–) mice infected intravenously with 2.5 × 105 SC5314 C. albicans. N = 6; combined data of two independent experiments. b, c Survival of wild-type and Epha2–/– mice infected intravenously with 2.5 × 105 (b; N = 12; combined data of two independent experiments) or 1.25 × 105 (c; N = 8; combined data of two independent experiments) SC5314 C. albicans. d Survival of bone marrow chimeric mice following infection with 2.5 × 105 SC5314 C. albicans. N = 7; combined data of two independent experiments. Epha2+/+ mice reconstituted with Epha2+/+ BM (WT→WT), Epha2+/+ mice reconstituted with Epha2–/– BM (KO→WT), Epha2–/– mice reconstituted with Epha2+/+ BM (WT→KO), and Epha2–/– BM to and Epha2–/– mice (KO→KO). Mantel–Cox Log-Rank test. Kidney fungal burden of infected mice after e 4 days and f 12 h of infection with 2.5 × 105. Results are median (N = 6) ±SEM of two independent experiments combined. ns, no significance. Two-tailed Mann–Whitney Test. g Apoptotic areas per kidney after 4 days of infection determined by TUNEL staining. N = 6; combined data of two independent experiments. Two-tailed Mann–Whitney Test. Box-and-whisker plots indicating median, 25th/75th percentiles, and the minimum/maximum values. h Serum and kidney NGAL, and I serum TREM1 levels after 3 days of infection. Results are median (N = 6) ±SEM of two independent experiments combined. Two-tailed Mann–Whitney Test. j Survival of wild-type and Epha2−/− mice injected intraperitoneally with 750 mg/kg of zymosan. N = 5; combined data of two independent experiments. Mantel–Cox Log-Rank test.
