Fig. 1: Standard biomarkers of short-term fasting in healthy humans and mice.
From: Fatty acids homeostasis during fasting predicts protection from chemotherapy toxicity
a, b Scheme of the protocols followed for the short-term fasting experiment in humans (a) and mice (b). Green arrows indicate the times of fasting, and white arrows indicate normal feeding. Red arrows indicate blood sampling; blue arrows indicate chemotherapy administration, and black arrows indicate sacrifice. c–f Blood levels in human volunteers of glucose (c), insulin (d), β-hydroxybutyrate (β-HB, e) and free fatty acids (FFAs, f) at the basal point after 12 h of overnight fasting (B); after 36 h of fasting (F); and after 12 h of refeeding and 12 h of overnight fasting (R). g–i Blood levels of glucose (g), insulin (h) and β-HB (i) in fed conditions at first time in the morning (Basal, B) and after 24 h of fasting (F). j Mouse body weight at the indicated times. Each dot represents the data from a single individual, and is linked with a straight black line with the data of the same individual in the next point of the time course experiment. Statistical significance was performed using the one-way ANOVA test with Tukey correction for multiple comparisons (c–f); or the paired two-tailed Student t test (g–j). The exact p value is provided for each significant comparison. Source data are provided as a Source Data file.
