Fig. 5: Microglia–macrophage reprogramming in the TBME.
From: The spatial transcriptomic landscape of non-small cell lung cancer brain metastasis
a Heatmap of differential expression of specific genes for the M1 and M2 macrophages in the F(h) vs. F(−) TBME. b Violin plots showing the significant differences in expression of CD163, TGFB1, CXCL10, and SPI1 between the F(h) vs. F(−) TBME. The dashed and solid lines within the plots indicate upper and lower quartiles and medians, respectively. c Heatmap of differentially expressed myeloid signature gene in the TBME and BC ROIs, n = 8, 6, 5, and 7 samples in F(−), F(h), F(I), and BC, respectively. d Heatmap of differential microglia signature gene expression in the F(h) vs. F(−) TBME. e. Violin plots showing the significant differences in expression of selective microglia markers, n = 8 and 6 samples in F(−) and F(h), respectively. The dotted lines indicate upper and lower quartiles, whereas the solid lines represent medians. a, c, d P < 0.05, Student’s t test (two-sided). The P values in (b, e) were based on Mann–Whitney test (two-sided). Heatmaps colored from blue to red according to Z-score scale −2 to 2. Source data are provided as a Source Data file.
