Fig. 7: ANGEL2 phosphatase activity is required for the maturation of mRNAs that undergo non-canonical processing. | Nature Communications

Fig. 7: ANGEL2 phosphatase activity is required for the maturation of mRNAs that undergo non-canonical processing.

From: ANGEL2 phosphatase activity is required for non-canonical mitochondrial RNA processing

Fig. 7: ANGEL2 phosphatase activity is required for the maturation of mRNAs that undergo non-canonical processing.The alternative text for this image may have been generated using AI.

Model of the non-canonical processing of mitochondrial RNA. The mitochondrial RNA polymerase, POLRMT, transcribes long, polycistronic transcripts, which are cleaved by RNase P and ELAC2 at the tRNA gene junctions. Non-canonical junctions are recognised by members of the FASTK family (FASTK*), resulting in the formation of 3′ phosphates. Phosphatase activity by ANGEL2 hydrolyses the 3′ ends of mt:Nd5 and mt:Atp8/6, allowing further their polyadenylation by the mitochondrial poly(A) polymerase, MTPAP.

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