Fig. 1: Recurrently dysregulated super-enhancers in CRC patients. | Nature Communications

Fig. 1: Recurrently dysregulated super-enhancers in CRC patients.

From: A local tumor microenvironment acquired super-enhancer induces an oncogenic driver in colorectal carcinoma

Fig. 1: Recurrently dysregulated super-enhancers in CRC patients.

a Study overview. Figure adapted from SMART Servier Medical Art, reproduced with permission, licensed under a Creative Commons Attribution 3.0 unported license. b PCA of H3K27ac signal at 2026 SEs in CRC (n = 15 independent tissue samples), normal mucosa (n = 15), crypts (n = 4), and FAP adenomas (n = 2). c, d GSEA between SE proximal genes and differentially expressed genes between CRC and normal. e H3K27ac ChIP-seq track near ASCL2. Two proximal SEs are underlined. The y-axes of all ChIP-seq tracks are scaled the same. f 2026 SEs by log2 fold change in H3K27ac signal with 12 candidate SE target genes based on overlap of ranking and recurrence annotated. g Heatmap of H3K27ac signal at 583 differentially expressed SEs (P < 0.01, two-sided Student’s t test). Source data are provided as a Source Data file. NES normalized enrichment score, FDR false discovery rate.

Back to article page