Fig. 4: Consensus clustering of proteomics profiles partitioned CLL into six subgroups.
From: Proteogenomics refines the molecular classification of chronic lymphocytic leukemia
a Consensus clustering partitioned CLL samples into six proteomics groups (PGs). The color scale indicates which proportion of iterations patients clustered together. b Annotation of PGs with genetic alterations and pretreatment status. c Comparison of proteomic-based with transcriptomic-based consensus clustering. n = 58 biologically independent samples. d The PGs had significantly different times to next treatment (TTNT; log-rank test, p < 0.0001). Only patients for whom TTNT was available are shown. e Lymphocyte growth rates for Tris12M-PG (n = 4), Tris12U-PG (n = 4), M-PG (n = 14), U-PG (n = 10), and New-PG (n = 3) biologically independent samples. Kruskal–Wallis test p = 0.0086. No data for TP53-PG was available. Boxplots are represented as first and third quartiles with a median in the center. Whiskers are defined as 1.5 times the interquartile range. Source data are provided as a Source Data file.
