Fig. 8: Proposed model for TRB1-VAP27 mediated Mitochondria-ER interaction and mitophagy. | Nature Communications

Fig. 8: Proposed model for TRB1-VAP27 mediated Mitochondria-ER interaction and mitophagy.

From: TraB family proteins are components of ER-mitochondrial contact sites and regulate ER-mitochondrial interactions and mitophagy

Fig. 8

a Under normal conditions, mitochondria are tethered to the ER through the TRB1-VAP27 complex at EMCSs; this link is essential for mitochondrial function (e.g., movement, morphology, and energy metabolism). b TRB1 also interacts with ATG8, a function that is essential for the mitochondrial stress-response. When the number of damaged mitochondria increases, TRB1 recruits ATG8 at the EMCS to regulate the formation of mitophagosomes. VAP27 may also recruit other unidentified autophagy proteins, such as ULK1/ATG1 and WIPI2/ATG18 to facilitate autophagosome maturation, as has been reported in mammalian cells. The model was created with BioRender.com.

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