Fig. 3: TERRA interacts with DNA repair proteins in ALT cancer cells. | Nature Communications

Fig. 3: TERRA interacts with DNA repair proteins in ALT cancer cells.

From: XPF activates break-induced telomere synthesis

Fig. 3

a RNA slot blotting shows the enrichment of TERRA RNA after iDRiP capture in U2OS cells. Two independent experiments show similar results. b Quantification of TERRA derived from chromosome 2q by qRT-PCR. Bars, mean ± SD. Representative of four independent experiments. c Volcano plot showing proteome abundance of TERRA iDRiP-MS normalized with luciferase iDRiP-MS. P-values calculated by Rank Product method. d TERRA interacting proteins are subclassified into functional groups. Data of TERRA-iDRiP-MS enriched proteins from four biological replicates. e Gene Ontology analysis of TERRA interacting proteins identified enriched pathways by DAVID bioinformatics resources. P-values by Fisher Exact test. Benjamini FDR was shown.

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