Fig. 1: Schematic illustration of the mechanism for visible light-triggered photocatalytic therapy of diabetic wound based on HTON.
From: Photocatalytic glucose depletion and hydrogen generation for diabetic wound healing
HTON as a VIS-responsive photocatalyst possesses a right energy band structure which enables to utilize glucose (Glu) in the high-glucose microenvironment as a sacrificial agent for efficient VIS-photocatalytic hydrogen generation. Photocatalytic glucose depletion and generated hydrogen molecules inhibit the synthesis of advanced glycation end products (AGEs) and the expression of their receptors (RAGE) in the microenvironment of diabetic wound, respectively, jointly blocking the apoptosis of skin cells and promoting their proliferation and migration in support of efficient diabetic wound healing.
