Fig. 1: Age impacts the predictive power of eQTLs in many tissues.
From: Tissue-specific impacts of aging and genetics on gene expression patterns in humans
a A hypothetical model of the differing power to detect eQTLs in old and young cohorts. b Examples of gene expression binned by genotype and age for four genes in which eQTL p-values differ between old and young individuals in whole blood and heart atrial appendage. Example genes with both positive and negative effects are shown. n = 309 samples for old group in blood, n = 361 samples for young group in blood, n = 202 samples for old group in heart atrial appendage, n = 170 samples for young group in heart atrial appendage. Center line of the boxplot indicates median, box limit indicates first and third quartiles and points indicate outliers. c QQ plots of eQTL p-values (plotted as -log(P)) for old (red) and young (blue) individuals from a linear model correlating expression with the lead SNP for each gene in 27 tissues (Supplementary Data 2). P-values for significant differences in eQTL p-value distributions are obtained from a two-sided Welch's t-test.
