Fig. 4: Functional analysis of age-related genes reveals enriched biological processes.
From: Tissue-specific impacts of aging and genetics on gene expression patterns in humans
a A QQ plot of p-values for pathways tested for enrichment using gene set enrichment analysis (GSEA) with genes ranked by either h2 or \({R}_{{{{{{{{\rm{age}}}}}}}}}^{2}\) in four example tissues. b GSEA enrichments from genes ranked by the mean βage across tissues. P-values were obtained using two-sided permutation test. Pathways with a multiple testing corrected P < 0.02 are shown. c Average gene expression variance explained by age for mitochondrial (MT) genes (red), translation factor genes (purple), interferon gamma genes (blue) and remaining genes (yellow) across all tissues, error bar indicating standard error of mean. d Volcano plot of the variance explained by age vs βage for mitochondrial, translation factors, interferon gamma factors, and remaining genes. Density plot of each axis shown on top and right.
