Fig. 4: Visualizing rheumatoid arthritis mouse with CDr17.
From: Visualizing inflammation with an M1 macrophage selective probe via GLUT1 as the gating target
A Workflow of rheumatoid arthritis (RA)-induced mice preparation. B In vivo fluorescence images of RA and control at different time post-injection of CDr17 and C the average fluorescent intensity (FI) of CDr17 was plotted into the graph. Data are presented as mean ± SD. (n = 3, biologically independent mice per group). D Correlation between joint swelling grade and fluorescent intensity of CDr17 after 15 min injection in RA. E Scheme of tissue imaging post i.v. injection of CDr17. F CDr17 strongly stained macrophages in RA-induced mice, confirmed by anti-CD68. Scale bar, 20 µm. All the images were acquired at ×20 magnification. Data are presented as mean values ± SD (n = 3). Error bars: standard deviation from three independent measurements. Scale bar, 50 µm. Source data are provided as a Source data file.
