Fig. 4: Genomic summary of significantly mutated genes (SMGs) in SCC cohorts.

The central plot shows mutation type and frequencies for 34 SMGs identified using dNdSCV on TCGA, Bergen and Ugandan cohorts (367 total patients). The histogram above the main plot represents tumour mutation burden (TMB, mutations/megabase) per sample. The histogram to the left displays the statistical significance of each SMG while the histogram to the right represents the proportion of C1 (blue) and C2 (red) tumours in which each gene is mutated. Black outlines around bars in this histogram signify a significant difference (FDR < 0.05, Wald Test) in mutation frequency between clusters. The stacked histogram below the main plot represents the breakdown of single base mutational signatures (SBS) detected in each tumour. Gene name key: blue = SMG in C1 tumours; red = SMG in C2 tumours; black = SMG in C1 and C2 tumours; black * = SMG only when combining C1 and C2 tumours; † = SMG not previously reported in cervical cancer; ‡ = SMG in C1 tumours but not significant when C2 tumours also included.