Table 1 Genes included in STRAC11, STRAC13, and STRAC14

STRAC13 and STRAC11

AMT

Aminomethyltransferase (Glycine Cleavage System Protein T)

STRAC13

CXCR1

High Affinity Interleukin-8 Receptor A; recruits immune suppressive cells such as the myeloid-derived suppressor cells to the tumor microenvironment

ATG14

Autophagy-Related Protein 14-Like Protein; regulates cytoprotective autophagy (role in drug resistance)

FPR2

Formyl Peptide Receptor 2; promotes invasion and metastasis of some cancers

SPIN3

Spindlin-Like Protein 3; a tumor suppressor, pro-apoptotic, downregulates CYCD1

ZNF415

Zinc Finger Protein 415; involved in transcriptional regulation; promoter aberrantly hypermethylated in oropharyngeal squamous cell carcinoma

THEM4

Thioesterase Superfamily Member 4; facilitates apoptosis by negatively regulating Akt/PKB signaling

TXNIP

Thioredoxin Interacting Protein; a tumor suppressor in various cancers; regulate the metabolism and division of cells by inhibiting their ability to take up glucose

ADHFE1

Hydroxyacid-Oxoacid Transhydrogenase; a breast cancer oncogene

UFSP1

UFM1-Specific Peptidase 1 (non-functional)

ZKSCAN7

Zinc Finger With KRAB And SCAN Domains 7; may be involved in transcriptional regulation

BIRC7

Baculoviral IAP Repeat Containing 7; inhibits apoptosis by inhibiting proteolytic activation of capsases

HIST2H3A

H3 Clustered Histone 15; core component of nucleosome

STRAC11

APOBEC3A

Apolipoprotein B MRNA Editing Enzyme Catalytic Subunit 3A; induces mutagenesis in cancer cells, and contributes to tumor evolution

PRKAB1

Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 1; a regulatory subunit of the AMP-activated protein kinase (AMPK), can act as either a tumor suppressor (prevent tumorigenesis) or a tumor promoter (after tumorigenesis occurred)

MROH8

Maestro Heat Like Repeat Family Member 8

SLPI

Secretory Leukocyte Peptidase Inhibitor; modulates the inflammatory and immune responses and the promotion of cell proliferation

TDO2

Tryptophan 2,3-Dioxygenase; may play a role in cancer through the suppression of antitumor immune responses

SNX29

Sorting Nexin 29; circular RNA derived from this gene reduced myoblast proliferation and promoted cell differentiation

SLC16A1

Solute Carrier Family 16 Member 1; a key controller of the cell cycle and mitosis, oncogene role in promoting cancer cell proliferation

MERTK

MER Proto-Oncogene, Tyrosine Kinase; regulates cell survival, migration, differentiation, and phagocytosis of apoptotic cells; increases tumor immunogenicity

ARRDC1

Arrestin Domain-Containing 1; a tumor suppressor in ccRCC in the Hippo pathway

STEAP1

Six Transmembrane Epithelial Antigen Of The Prostate 1; promotes proliferation, migration, invasiveness, and tumorigenicity

STRAC14

ECE2

Endothelin Converting Enzyme 2; involved in the processing of various neuroendocrine peptides

TMEM220

Transmembrane Protein 220

TOMM40

Translocase of Outer Mitochondrial Membrane 40; essential for import of protein precursors into mitochondria

NDUFS6

NADH:Ubiquinone Oxidoreductase Subunit S6; interact with CD147 in the mitochondria and may play a role in the multidrug resistance of cancer cells

NEB

Nebulin; muscle protein that may be involved in maintaining the structural integrity of sarcomeres and the myofibril’s membrane

ZNF727

Zinc Finger Protein 727; may be involved in transcriptional regulation

IRF6

Interferon Regulatory Factor 6; may be a transcriptional activator

ZNF483

Zinc Finger Protein 483; may be involved in transcriptional regulation

ACHE

Acetylcholinesterase (Cartwright Blood Group); has a role in neuronal apoptosis

LIPC

Hepatic Triacylglycerol Lipase; plays a role in in cancer progression and metastasis

RAB3IL1

RAB3A Interacting Protein Like 1; may have a role in synaptic vesicle exocytosis

SAMD15

Sterile Alpha Motif Domain-Containing 15

MTMR8

Myotubularin Related Protein 8; in complex with MTMR9, negatively regulates autophagy

PKP1

Plakophilin 1; may be involved in molecular recruitment and stabilization during desmosome formation