Fig. 7: A potential hotspot for DUB ligandability across families.
From: Structural basis for specific inhibition of the deubiquitinase UCHL1
a–d Selection of structurally characterized DUB inhibitors of USP1450 (a), USP744,51 (b), SARS PLpro52 (c), and UCHL1 (d). Shown are the structures of the compounds, a close-up view of their binding pockets from co-crystal structures, and overlays of these co-crystal structures with Ubiquitin-bound structures of the respective DUBs. The Leu73 position is indicated with black arrows. The chemical moieties of the inhibitors that occupy the position of Leu73 of Ubiquitin are highlighted with a beige background.
