Table 4 Risk and cumulative incidence of CCS categories in the case vs. controls

From: Post-acute sequelae of SARS-CoV-2 with clinical condition definitions and comparison in a matched cohort

CCS Condition with Time Period

Case Cumulative Incidence

Control Cumulative Incidence

Risk Ratio [95% CI]

Total - Any condition

Late

26.1%

25.2%

1.04 [1.01,1.07] *

Acute and persistent

20.4%

22.1%

0.92 [0.89,0.95] *

Pre-existing conditions

46.1%

44.2%

1.04 [1.02,1.06] *

Total - PASC related conditions

Late

13.6%

12.1%

1.12 [1.08,1.16] *

Acute and persistent

4.1%

2.5%

1.60 [1.48,1.72] *

Pre-existing conditions

30.7%

29.0%

1.06 [1.03,1.08] *

Abdominal pain

Late

1.8%

1.7%

1.05 [0.95,1.17]

Acute and persistent

0.2%

0.2%

0.87 [0.63,1.20]

Pre-existing conditions

3.4%

3.4%

1.00 [0.93,1.07]

Anosmia

Late

0.3%

0.1%

3.88 [2.79,5.40] *

Acute and persistent

0.0%

0.0%

0.50 [0.11,2.28]

Pre-existing conditions

0.0%

0.0%

1.25 [0.31,5.00]

Anxiety disorders

Late

1.1%

1.1%

1.01 [0.89,1.15]

Acute and persistent

0.2%

0.3%

0.83 [0.63,1.10]

Pre-existing conditions

2.8%

3.6%

0.78 [0.72,0.84] *

Cardiac dysrhythmias

Late

0.9%

0.7%

1.25 [1.08,1.45] *

Acute and persistent

0.3%

0.2%

1.90 [1.45,2.49] *

Pre-existing conditions

1.6%

1.5%

1.02 [0.91,1.14]

Conditions associated with dizziness or vertigo

Late

1.7%

1.6%

1.05 [0.94,1.16]

Acute and persistent

0.2%

0.2%

1.08 [0.82,1.44]

Pre-existing conditions

3.6%

3.4%

1.04 [0.96,1.12]

Diabetes

Late

0.9%

0.8%

1.20 [1.03,1.38] *

Acute and persistent

0.3%

0.2%

1.96 [1.50,2.55] *

Pre-existing conditions

11.5%

9.3%

1.23 [1.18,1.29] *

Fluid and electrolyte disorders

Late

0.4%

0.6%

0.73 [0.59,0.90] *

Acute and persistent

0.2%

0.1%

1.96 [1.41,2.74] *

Pre-existing conditions

0.7%

0.8%

0.82 [0.69,0.97] *

Genitourinary symptoms and ill-defined conditions

Late

1.5%

1.2%

1.21 [1.07,1.36] *

Acute and persistent

0.1%

0.1%

1.14 [0.75,1.74]

Pre-existing conditions

2.1%

2.0%

1.04 [0.94,1.14]

Gastrointestinal Disease

Late

1.7%

1.7%

1.00 [0.90,1.12]

Acute and persistent

0.4%

0.4%

0.98 [0.79,1.21]

Pre-existing conditions

3.4%

4.0%

0.84 [0.78,0.90] *

Malaise and fatigue

Late

1.4%

0.9%

1.60 [1.41,1.81] *

Acute and persistent

0.3%

0.1%

2.89 [2.10,3.98] *

Pre-existing conditions

1.0%

0.9%

1.15 [1.00,1.33] *

Mental health

Late

1.1%

1.2%

0.95 [0.83,1.08]

Acute and persistent

0.2%

0.3%

0.62 [0.45,0.86] *

Pre-existing conditions

4.0%

5.6%

0.71 [0.67,0.76] *

Nausea and vomiting

Late

0.7%

0.7%

0.95 [0.80,1.12]

Acute and persistent

0.1%

0.1%

0.81 [0.49,1.32]

Pre-existing conditions

0.6%

0.7%

0.84 [0.71,1.00]

Nonspecific chest pain

Late

1.7%

1.2%

1.39 [1.24,1.55] *

Acute and persistent

0.4%

0.2%

2.39 [1.85,3.10] *

Pre-existing conditions

1.8%

1.5%

1.25 [1.12,1.39] *

Other lower respiratory disease

Late

1.1%

1.2%

0.92 [0.80,1.04]

Acute and persistent

1.2%

0.5%

2.51 [2.15,2.92] *

Pre-existing conditions

12.2%

10.0%

1.21 [1.16,1.26] *

Other nervous system disorders

Late

0.7%

0.7%

1.04 [0.89,1.22]

Acute and persistent

0.1%

0.1%

0.97 [0.64,1.49]

Pre-existing conditions

1.3%

1.5%

0.87 [0.77,0.98] *

Other nutritional; endocrine; and metabolic disorders

Late

0.5%

0.4%

1.14 [0.93,1.40]

Acute and persistent

0.0%

0.1%

0.54 [0.30,0.99] *

Pre-existing conditions

0.4%

0.4%

0.82 [0.66,1.03]

Respiratory failure; insufficiency; arrest (adult)

Late

0.1%

0.1%

1.14 [0.73,1.80]

Acute and persistent

0.7%

0.0%

22.95 [14.78,35.64] *

Pre-existing conditions

0.3%

0.2%

1.72 [1.29,2.29] *

  1. * Represents risk ratios with p < 0.05: Time periods were defined as follows: Late: 30–120 days post COVID test date; Acute and persistent 0-30 days post COVID test date and persisted 30-120 days; Pre-existing conditions: four years prior to COVID test date. All risk ratios presented are unadjusted.