Table 6 Sensitivity analysis - risk and cumulative incidence of symptom-based CCS categories

From: Post-acute sequelae of SARS-CoV-2 with clinical condition definitions and comparison in a matched cohort

CCS Category and Time Period

Mutually Exclusivea

Case Cumulative Incidence

Control Cumulative Incidence

Risk Ratio [95% CI]

Abdominal pain

Late

Yes

1.8%

1.7%

1.05 [0.95,1.17]

Late

No

5.4%

5.3%

1.01 [0.95,1.07]

Pre-existing conditions

Yes

0.2%

0.2%

0.87 [0.63,1.20]

Pre-existing conditions

No

0.8%

1.1%

0.73 [0.63,0.85] *

Anosmia

Late

Yes

0.3%

0.1%

3.88 [2.79,5.40] *

Late

No

0.3%

0.1%

3.21 [2.37,4.35] *

Pre-existing conditions

Yes

0.0%

0.0%

0.50 [0.11,2.28]

Pre-existing conditions

No

0.0%

0.0%

0.33 [0.08,1.46]

Conditions associated with dizziness or vertigo

Late

Yes

1.7%

1.6%

1.05 [0.94,1.16]

Late

No

5.5%

5.3%

1.04 [0.98,1.11]

Pre-existing conditions

Yes

0.2%

0.2%

1.08 [0.82,1.44]

Pre-existing conditions

No

1.1%

1.1%

1.02 [0.89,1.16]

Malaise and fatigue

Late

Yes

1.4%

0.9%

1.60 [1.41,1.81] *

Late

No

2.7%

1.9%

1.46 [1.33,1.60] *

Pre-existing conditions

Yes

0.3%

0.1%

2.89 [2.10,3.98] *

Pre-existing conditions

No

0.6%

0.3%

2.07 [1.69,2.54] *

Nausea and vomiting

Late

Yes

0.7%

0.7%

0.95 [0.80,1.12]

Late

No

1.4%

1.5%

0.90 [0.80,1.01]

Pre-existing conditions

Yes

0.1%

0.1%

0.81 [0.49,1.32]

Pre-existing conditions

No

0.2%

0.3%

0.61 [0.45,0.82] *

Nonspecific chest pain

Late

Yes

1.7%

1.2%

1.39 [1.24,1.55] *

Late

No

3.9%

2.8%

1.38 [1.28,1.49] *

Pre-existing conditions

Yes

0.4%

0.2%

2.39 [1.85,3.10] *

Pre-existing conditions

No

0.9%

0.5%

1.84 [1.56,2.16] *

  1. aMutually exclusive Yes represents our original analysis where pre-existing conditions were removed from calculating acute and persistent and late counts. Mutually exclusive No represents the sensitivity analysis where we allowed pre-existing conditions to be counted in the acute and persistent and late time periods. * Represents risk ratios with p < 0.05