Fig. 1: Ternary complex of SMARCA2^BD and VHL/Elongin C/Elongin B (VCB) induced by ACBI1 shows structural similarities to those induced by PROTAC 1 and PROTAC 2.

a Overall perspective of SMARCA2^BD and the VCB complex induced by degrader molecule ACBI1 (shown as yellow stick representation). b ACBI1-induced interface contacts between SMARCA2^BD and VHL. Annotated residues are among those that make the highest number of contacts (see panel c). c A contact map for the interface of the crystal structure (obtained by the Arpeggio software⁷⁰). Contacts are indicated when 10 atomic contacts (i.e., distance ≤ 4.5 Å) are present. d Superposition of the crystal structures of PROTAC 1 (PDB ID: 6HAY, purple), PROTAC 2 (6HAX, salmon), and ACBI1 (7SE4, green) by aligning VHL (orange surface representation) shows varied conformations of the three degraders (up to 2.0 Å at the warhead), resulting in minor alterations of SMARCA2^BD within the ternary complex.