Fig. 1: Schematic illustration of the mechanism of action of Synthetic RNA virus. | Nature Communications

Fig. 1: Schematic illustration of the mechanism of action of Synthetic RNA virus.

From: Development of intravenously administered synthetic RNA virus immunotherapy for the treatment of cancer

Fig. 1: Schematic illustration of the mechanism of action of Synthetic RNA virus.The alt text for this image may have been generated using AI.

Synthetic RNA virus is comprised of IVT-produced vRNA encapsulated within an LNP. Inside tumor cells, vRNA recapitulates all phases of the viral life cycle such that it replicates and generates a burst of infectious virions that spread locally, infecting, and killing tumor cells, thereby recruiting immune cells to the TME.

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