Fig. 7: Sleep deprivation causes cognitive impairment but not AD pathology. | Nature Communications

Fig. 7: Sleep deprivation causes cognitive impairment but not AD pathology.

From: Cholinergic basal forebrain degeneration due to sleep-disordered breathing exacerbates pathology in a mouse model of Alzheimer’s disease

Fig. 7

A The percentage of time spent in the novel arm of the Y maze on test, compared to the familiar arm. APP/PS1 mice displayed a preference for the novel arm, whereas sleep-deprived mice had no preference (P = 0.0477, control: P = 0.0050, Sleep-deprived: P = 0.1733). B The number of cBF neurons in C57Bl6 mice following sleep deprivation was equivalent to that of control mice (P = 0.624, Student’s unpaired two-tailed t-test). C The amount of soluble Aβ in hippocampal (age: P = 0.0602, cage: P = 0.774, interaction: P = 0.8960) and cortical (age: P = 0.0733, cage: P = 0.155, interaction P = 0.734) lysates as measured by ELISA was not altered by sleep deprivation. D The area of thioflavin-S-positive Aβ plaque in the hippocampus (age: P = 0.0330, cage: P = 0.9852, interaction: P = 0.6177) and cortex (age: P = 0.0128, cage: P = 0.410, interaction P = 0.666) of APP/PS1 mice was affected by age but not by sleep deprivation. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, n.s., non-significant. two-way ANOVA, Sidak’s multiple comparisons for panels (A, C, and D). Results are presented as mean of pooled age groups ± s.e.m. Each data point represents an individual animal. Source data are provided in the Source Data file.

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