Table 1 Detailed study designs

From: ChAd155-RSV vaccine is immunogenic and efficacious against bovine RSV infection-induced disease in young calves

Study

Colostrum feedinga

Sero-statusa

Treatments

DOI (weeks) before challenged

N

Test articleb (i.m.; 2 mL/dose)

No. of doses

Age at vaccine administration (weeks)c

1

No

–

ChAd155-RSV

2

6, 10

4

8

No

–

Placebo

2

6, 10

4

8

No

–

ChAd155-RSV

1

10

4

8

No

–

ChAd155-RSV

2

6, 10

16

8

No

–

Placebo

2

6, 10

16

7

2

Yes

Ab−

ChAd155-RSV

1

6

16

9

Yes

Ab−

Placebo

1

6

16

9

Yes

Ab+

ChAd155-RSV

2

6

4

9

Yes

Ab+

Placebo

2

6

4

9

Yes

Ab−

ChAd155-RSV

2

6

4

9

  1. aIn Study 1, calves received only antibody-negative milk replacer. In Study 2, a single feeding with anti-bRSV antibody-negative/-positive (Ab−/+) colostrum was supplied followed by feeding with antibody-negative milk replacer.
  2. bChAd155-RSV at 5 × 1010 viral particles/dose or phosphate-buffered saline, given by intramuscular (i.m.) injection.
  3. cAll animals in a given group were born within a 3–4-day period.
  4. dDuration of immunity (DOI) period (weeks since last vaccine administration) was followed by bRSV challenge at 3.2 (Study 1) or 3.7 (Study 2) log10 TCID50/2 mL dose. Necropsy was performed on days 12/13 post challenge for all groups.
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