Fig. 5: Validation of CAPITAL on different scRNA-seq datasets of human bone marrow cells.
From: Alignment of single-cell trajectory trees with CAPITAL
a A UMAP plot of clustering results of Setty et al.'s data. A trajectory tree predicted by CAPITAL is shown by a thick black line, where the solid lines indicate the linear trajectories that are compared in (d) and (e), whereas the dashed lines represent the others. b A UMAP plot of Velten et al.'s data. c An aligned tree of the trajectories of clusters, where each pair of numbers in a node denotes the clusters shown in (a) and (b). # denotes a space, meaning that it has no aligned cluster pair. d Cell–cell matchings along the trajectory paths from root (4/HSC, 0/HSC) to (22/Mega, 13/Mega) and to (18/DC, 11/Mono/DC), respectively, which result from the alignment of the single cells in pseudotime order via dynamic time warping. Note that the cells in each dataset have the same color as the corresponding UMAP plot. e Pseudotime aligned kinetics for megakaryocyte and monocyte/dendritic cell markers. UMAP uniform manifold approximation and projection, HSC hematopoietic stem cell, CLP common lymphoid progenitor, DC dendritic cell, Eo/Baso eosinophil/basophil, Ery erythrocyte, Mega megakaryocyte, Mono monocyte, Neutro neutrophil.
