Fig. 8: Suggested modifications of berberine enabling additional interaction with the KRAS-G4. | Nature Communications

Fig. 8: Suggested modifications of berberine enabling additional interaction with the KRAS-G4.

From: Structural insight into the bulge-containing KRAS oncogene promoter G-quadruplex bound to berberine and coptisine

Fig. 8: Suggested modifications of berberine enabling additional interaction with the KRAS-G4.The alternative text for this image may have been generated using AI.

The black circles indicate the positions to be modified by introducing side chains for groove interactions. The black arrows show the grooves at 5′- and 3′-sites where the attached side chain will locate. The red circle suggests the positions to introduce hydrogen bonds between berberine and thymine T10. The KRAS-G4 is shown in cartoon representation. Cyan, guanine; magenta, adenine; blue, thymine; orange, cytosine; yellow, berberine.

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