Fig. 6: IgG-Fab arms cause a steric hindrance when IgG is bound to membrane-associated FcRn.
From: The Fab region of IgG impairs the internalization pathway of FcRn upon Fc engagement
a Graphical illustration of potential steric hindrance caused by the Fab arms when an IgG binds membrane-associated FcRn. b Crystal structure of FcRn bound to IgG in a membrane context in the same “standing up” conformation as in (a2) and in the “lying down/reclined” conformation. The images were rendered using UCSF Chimera97 after combining structural data from ref. 98 (PDB: 1HZH) and ref. 25 (PDB: 1I1A) by comparative homology modeling using the matchmaker function of UCSF Chimera.
