Fig. 5: Neutralising and binding SARS-CoV-2 antibody responses one and 3 months after vaccination in context of breakthrough in the Nigerian cohort.

a Serum neutralization against pseudotyped virus from individuals with vaccine breakthrough occurring between months 1 and 3 post second dose and with no evidence of previous infection prior to vaccine (n = 8, N antibody +ve), and those without breakthrough or past infection prior to vaccine (n = 15, N antibody −ve). b Total anti-spike binding IgG levels in individuals with breakthrough infection between 1 and 3 months post vaccination (n = 8) and with no evidence of ‘natural’ infection (n = 15). Data points were compared using Wilcoxon test and shown as geometric mean titre (GMT) with 95% CI. Data are representative of two independent experiments comprising of two technical replicates. *P < 0.05.