Fig. 8: Proposed mechanism for the inhibition of renal fibrosis by B. fragilis.
From: The gut microbe Bacteroides fragilis ameliorates renal fibrosis in mice
The relative abundance of B. fragilis is decreased in the feces of CKD patients and UUO mice. Oral administration of live B. fragilis attenuates renal fibrosis in UUO and adenine mice models. Increased LPS levels are decreased after B. fragilis administration. 1,5-AG, a substrate of SGLT2, increases after B. fragilis administration via enhancement of renal SGLT2 expression. 1,5-AG is an agonist of TGR5 that attenuates renal fibrosis by inhibiting oxidative stress and inflammation. Mad promotes B. fragilis growth and remarkably ameliorates renal fibrosis.
