Fig. 4: Sucrose intake elicits distinct transcriptional responses in adipose tissue from male and female mice. | Nature Communications

Fig. 4: Sucrose intake elicits distinct transcriptional responses in adipose tissue from male and female mice.

From: Chronic intake of high dietary sucrose induces sexually dimorphic metabolic adaptations in mouse liver and adipose tissue

Fig. 4: Sucrose intake elicits distinct transcriptional responses in adipose tissue from male and female mice.

a Heat maps demonstrate a difference in the number of transcripts differentially expressed in inguinal adipose tissue following chronic liquid sucrose intake in each sex, as determined using negative binomial generalized models and Wald tests with Bonferroni correction in DESeq2 (MC: n = 8, MS: n = 8, FC: n = 8, FS: n = 8). b Bubble plot of the differentially expressed transcripts common to both male and female mice following sucrose intake demonstrating the log2-fold change (vertical spread), adjusted p-values (horizontal spread) and normalized count value (bubble size) for each sex as determined in a. c Top 25 gene sets enriched according to the Hallmark database. NES normalized enrichment score, M male, F female, Add additive effect of sex on the effect of sucrose intake, Int. sex sucrose interaction effect, MC Male Control, MS Male Sucrose, FC Female Control, FS Female Sucrose. Relative transcript expression, including Log2 fold change and adjusted p-values are available in Supplementary File 2, Gene Set Enrichment Analyses are available in Supplementary File 4, and raw data are available from the NCBI Gene Expression Omnibus, accession number GSE151358.

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