Fig. 3: Within a single donor, antigen directed IgG1 clones display distinctive cross-reactivity versus the VOCs S-protein variants.

a Quantitative comparison of the ten most abundant IgG1 Fab clones, affinity-enriched from the plasma of donor 003, with each of the four S-protein variants. Each bar represents one of the 10 most abundant clones with the height indicating the concentration in µg/ml, using the same colors for the clones corresponding to panel (b). Each clone that was not in the total top 10 but was in the top 10 for that specific VOC is colored grey. Source data are provided as a Source Data file. b Top 10 most abundant clones with their relative abundance after the pull-down with each of the four VOCs S-protein variants. The colored bars in a and the dotted lines in the radar plot in c are corresponding to the clones in the table B. c Radar plot with on each edge the data for one of the S-protein variants. These plots depict the difference in binding of specific clones against the VOCs S-protein variants. The thick solid black line representing the sum of all enriched IgG1 clones. Color coding is identical as used in a and b. Source data are provided as a Source Data file. The magnifying glass used in this figure was retrieved via Wikipedia.