Fig. 7: Mutant p53 in normal epithelia in carcinogenesis. | Nature Communications

Fig. 7: Mutant p53 in normal epithelia in carcinogenesis.

From: p53 mutation in normal esophagus promotes multiple stages of carcinogenesis but is constrained by clonal competition

Fig. 7

Heterozygous p53 mutation in single cells in normal epithelia confers a proliferative advantage, clonal expansion, and a population of mutant cells that persists to undergo LOH. Clones with LOH are rare, but those that persist may acquire CNA and progress to form tumours. Once a tumour has formed, p53 mutation enhances tumour growth.

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