Fig. 5: Immature and mature OSN axons innervating the M72 glomerulus show similar odorant selectivity. | Nature Communications

Fig. 5: Immature and mature OSN axons innervating the M72 glomerulus show similar odorant selectivity.

From: Immature olfactory sensory neurons provide behaviourally relevant sensory input to the olfactory bulb

Fig. 5: Immature and mature OSN axons innervating the M72 glomerulus show similar odorant selectivity.

a Glomeruli in OMP-GCaMP6s and Gγ8-GCaMP6s mice respond to a similar number of odorants in a seven-odorant panel (Wilcoxon signed rank test. P = 0.95, W = −2, n = 186 glomeruli in 6 OMP-GCaMP6s mice and 150 glomeruli in 6 Gγ8-GCaMP6s mice). b Similar lifetime sparseness of glomerular odorant responses in OMP-GCaMP6s and Gγ8-GCaMP6s mice (Nested t-test. P = 0.97, t = 0.037. n = 120 responding glomeruli in 6 OMP-GCaMP6s mice and 97 responding glomeruli in 6 Gγ8-GCaMP6s mice). Lines: mean values for each mouse, symbols: individual glomeruli. c Camera image showing M72 glomerulus (magenta) and baseline GCaMP6s fluorescence (green) in mature OSN axons in vivo through a cranial window. d Camera image showing M72 glomerulus (magenta) and baseline GCaMP6s fluorescence (green) in immature OSN axons in vivo through a cranial window. e Mature and immature OSN axons in lateral M72 glomeruli respond to a similar number of odorants (Nested t-test. P = 0.36, t = 1.03, n = 6 glomeruli from 3 OMP-GCaMP6s-M72-RFP mice and 5 glomeruli from 3 Gγ8-GCaMP6s-M72-RFP mice). Lines: mean for each mouse, symbols: individual M72 glomeruli. f Lifetime sparseness of odorant responses of mature and immature OSN axons in lateral M72 glomeruli is similar (Nested t-test. P = 0.70, t = 0.42, n = 6 glomeruli from 3 OMP-GCaMP6s-M72-RFP mice and 5 glomeruli from 3 Gγ8-GCaMP6s-M72-RFP mice). Bars: mean for each mouse, symbols: individual M72 glomeruli. Long bar in Gγ8 group represents two mice. All statistical tests were two-tailed. Source data are provided as a Source Data file.

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