Fig. 3: Unciliated glandular epithelium is the source of endometrial carcinoma.

a Split t-SNE plots of Fig. 1b for detail clusters show that clusters 14 and 28 are arising during tumor progression. b, c t-SNE plot of unciliated epithelium cell of normal and EEC showing distribution (b) and marker genes pattern (c) of glandular cell, luminal cell, and oncogenic subpopulation. d RNA velocity upon UMAP plot of epithelial cells of normal and EEC suggests that oncogenic subpopulation is generated from unciliated glandular cell. The red triangle indicates the initial position of RNA stream. e Projection of ‘oncogenic subpopulation’ on the t-SNE plot of normal and AEH unciliated epithelial cells, carried out by the TransferData function developed by Seurat team.