Fig. 7: Disruption of immune environment from normal to EEC.

a t-SNE plot of different cell types of immune cells from normal, AEH and EEC. b The proportion of different immune cell types at different stages of endometrial pathology. Data are mean ± SEM based on five independent biological replicates. P-value was analyzed by comparing with AEH or EEC versus normal group and there was no significance (t test for each group, two-sided, and p-values are denoted above). c t-SNE plot showing macrophage subtypes. d The expression of the signature gene of different macrophage subtypes. e The proportion of different subtypes in macrophage at different stages of endometrial pathology. Data are mean ± SEM based on five independent biological replicates. P-value was analyzed by comparing with AEH or EEC versus normal group and there was no significance (t test for each group, two-sided, and p-values are denoted above). f GO enrichment analysis of differential genes in each macrophage subtype. P-values are analyzed by Fisher’s exact test, one-sided. g t-SNE plot showing T lymphocyte subtypes. h The expression of signature genes of T lymphocyte subtypes. i The proportion of different T lymphocytes subtypes at different stages of endometrial pathology. Data are mean ± SEM based on five independent biological replicates. P-value was analyzed by comparing with AEH or EEC versus normal group (t test for each group, two-sided, and p-values are denoted above). Source data are provided as a Source Data file.