Fig. 4: Molecular basis for the prolonged and transient cAMP signaling of PTH1R.
From: Molecular insights into the distinct signaling duration for the peptide-induced PTH1R activation
a Structural comparisons of the peptide–bound PTH1R with and without G-protein coupling (ePTH–bound; PDB 6FJ3). b, d, Duration of cAMP signaling responses induced by PTH, ABL and LA-PTH analogs. c, e Interactions of the peptide residues (positions 5 and 11) with RG and R0 state PTH1R, respectively. Potential interactions of peptide agonists with R0 state receptor were analyzed based on the template of ePTH-bound PTH1R. (PDB 6FJ3). Source data are provided as a Source Data file.
