Fig. 5: The relationship between Ag85A-specific IgG response and BCG-specific IFN-γ response.

a Spearman Correlation between Ag85A-specific IgG response on Day −7 (Left) or Day28 (middle and right) and BCG-specific IFN-\(\gamma\) response. Day −7 and Day 28 samples are included in the upper panel and only Day −7 samples are included in the bottom panel (Only unadjusted p-values are shown). For Ag85A-specific IgG response on Day −7, combined MVA85A-vaccinated and placebo group infants’ data were analysed. For Ag85A-specific IgG response on Day 28, MVA85A-vaccinated and placebo group infants’ data were analysed separately. Hypothesis testing used to generate p-values for the spearman correlation was two-sided. P-values were not adjusted. OD values are displayed for antibody response. b The distribution of BCG specific IFN-\(\gamma\) response for all samples (both Day −7 and Day 28 samples are included). c Ag85A-specific IgG response on Day −7 (Left) or Day28 (middle and right) in BCG T-cell responders (ELISpot BCG response > 60 SFC) and non-responders (ELISpot BCG response \(\le\) 60 SFC) (only unadjusted p-values are shown). For Ag85A-specific IgG response on Day −7, combined MVA85A-vaccinated and placebo group infants’ data were analysed together. For Ag85A-specific IgG response on Day 28, MVA85A-vaccinated and placebo group infants’ data were analysed separately. Two-sided Mann-Whitney test without multiple testing correction was used. Bars show medians with interquartile ranges (IQR), the upper whisker extends to the largest value no further than 1.5\(\times\) IQR from the hinge, the lower whisker extends from the hinge to the smallest value at most 1.5\(\times\) IQR from the hinge. N = 132/26, 120/25, 54/15, 47/15, 59/9 and 54/8 for biologically independent samples from BCG T-cell responders/nonresponders in the left top, left bottom, middle top, middle bottom, right top and right bottom, respectively. OD values are displayed for antibody response. Source data are provided as a Source Data file.