Fig. 5: A proposed model for differential recycling routes of Ptp10D and EGFR in epithelial tissues. | Nature Communications

Fig. 5: A proposed model for differential recycling routes of Ptp10D and EGFR in epithelial tissues.

From: WASH activation controls endosomal recycling and EGFR and Hippo signaling during tumor-suppressive cell competition

Fig. 5: A proposed model for differential recycling routes of Ptp10D and EGFR in epithelial tissues.The alternative text for this image may have been generated using AI.

In the sorting endosomes, EGFR and Ptp10D located into different subdomains and follow bifurcated recycling routes. Ptp10D is recycled by the WASH/retromer complex while EGFR is predominantly recycled by the WASH/retriever/CCC complex. The efficiency of these recycling routes is regulated by endosomal F-actin polymerization boosted by phospho-WASH. Dysregulation of retromer or retriever-dependent recycling routes leads to separation of EGFR from its negative regulator Ptp10D, allowing EGFR signaling activation and aberrant clonal growth.

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