Table 1 Interconversion times obtained from fFCS analysis for DNA in presence of PARP-1 and PARPi
From: Structural dynamics of DNA strand break sensing by PARP-1 at a single-molecule level
Dataset | τR, µs | |
|---|---|---|
DNA with F2 | 404 ± 63 | |
DNA with F1F2 | 265 ± 26 | |
DNA with PARP-1 | 273 ± 19 | |
Class I | DNA with PARP-1 and EB-47 | 236 ± 70 |
Class II | DNA with PARP-1 and olaparib DNA with PARP-1 and talazoparib | 241 ± 24 245 ± 88 |
Class III | DNA with PARP-1 and niraparib DNA with PARP-1 and veliparib DNA with PARP-1 and rucaparib | 328 ± 44 338 ± 60 365 ± 36 |
