Fig. 8: Endothelial alpha globin enhances blood pressure change in response to global hypoxia.

a In normoxia (room air), the systolic blood pressure of the Hba1^–/– and EC Hba1^Δ/Δ genotypes was slightly decreased when compared to other genotype groups. b When exposed to hypoxia, the Hba1^–/– and EC Hba1^Δ/Δ groups had slightly elevated systolic blood pressure when compared to other groups. c Hba1^–/– and EC Hba1^Δ/Δ mice showed the least change in systolic blood pressure difference between normoxia and hypoxia when compared to littermate controls and WT mice. This difference between groups was statistically significant. d Data points from individual animals plotted to show the change in systolic pressure from normoxia (filled circles) to hypoxia (open circles). e Heart rate in beats per minute (bpm) of the individual animals used for this experiment are plotted to show change when the animal was exposed to hypoxia. For these experiments, n = 7 C57Bl/6 mice, n = 6 Hba1^+/+ mice, n = 6 Hba1^–/– mice, n = 7 Hba1^fl/fl mice, n = 7 EC Hba1^Δ/Δ mice, n = 7 Hba1^WT/WT mice, and n = 7 Hba1^WT/Δ36–39 mice were used. Comparisons across groups used a one-way ANOVA; in e, only comparisons between paired values were calculated. Bar graphs are centered on mean with error bars denoting standard error. Source data are provided in the Source data file.