Fig. 1: Schematic representation of the experimental system. | Nature Communications

Fig. 1: Schematic representation of the experimental system.

From: Effective screening of Coulomb repulsions in water accelerates reactions of like-charged compounds by orders of magnitude

Fig. 1

a The reaction between negatively charged coenzymes A (CoA) is used as a model reaction. One of them—CoA-M—has fluorescent moiety. The reaction between reactants occurs through the substitution of bromine in the CoA-M by the thiol group of CoA. This process is practically irreversible, and as a product, CoA-M-CoA molecule is formed. b The product formation is accompanied by an increase in fluorescence intensity. c Here, we show how the charge screening and enhancement of local concentration of reactants at the oppositely charged molecules' surfaces increase reaction rates of Coenzyme A molecules. We investigate the reaction speed up in the aqueous solution in the presence of d ions and charged monomers, e zwitterions, f charged oligomers and polymers, and g charged micelles.

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