Fig. 2: Genome-wide associations for heart failure.
Results of the multi-ancestry GWAS meta-analysis of all-cause heart failure, performed using a fixed-effect inverse variance weighted model. A Manhattan plot of genome-wide significant (p < 5 × 10−8) associations. Each point represents a genetic variant. Variants in red are located +/−500 kb of a genome-wide significant locus. The x-axis represents the genomic position, and the y-axis represents the strength of association as represented by −log10(p value). B Candidate genes were assigned to each genome-wide significant variant (p < 5 × 10−8) in the multi-ancestry and ancestry-specific analyses (based on proximity to the nearest transcription start site). Candidate genes are grouped by chromosome. Previously unreported candidate genes (>500 kb from a previously reported locus) are denoted by stars. The size of each point corresponds to the strength of association as represented by −log10(p value). Where multiple independent variants mapped to the same gene, only the strongest association is shown.
