Fig. 3: Associations of heart failure risk variants with common cardiometabolic traits. | Nature Communications

Fig. 3: Associations of heart failure risk variants with common cardiometabolic traits.

From: Genome-wide association and multi-trait analyses characterize the common genetic architecture of heart failure

Fig. 3

Dotplot indicating associations between lead variants at heart failure risk loci (y-axis), with common cardiometabolic traits (x-axis), with summary estimates obtained from GWAS reported in the IEU OpenGWAS Project. Of the 47 lead risk variant for HF, 46 (or a proxy) were reported in at least 1 cardiometabolic trait GWAS. The size of each point denotes the absolute z-score for each trait, with reference to the heart-failure increasing allele. The shading of each point denotes whether the association met an FDR adjustment for multiple testing. Associations exceeding the conventional genome-wide significance threshold are denoted with a white circle. Variants are grouped by chromosome. FDR false discovery rate.

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