Fig. 4: Shared associations between heart failure and cardiac MRI traits. | Nature Communications

Fig. 4: Shared associations between heart failure and cardiac MRI traits.

From: Genome-wide association and multi-trait analyses characterize the common genetic architecture of heart failure

Fig. 4

A Cross-trait LD score regression was performed to estimate genetic correlations (rg) between heart failure and cardiac MRI traits. Significant associations using the Bonferroni method to account for multiple testing are noted with a star. B GWAS associations between lead heart failure risk variants and cardiac MRI traits. The size of each point denotes the absolute z-score for each trait, with reference to the heart failure increasing allele. The shading of each point denotes whether the association met an FDR adjustment for multiple testing. Associations exceeding the conventional genome-wide significance threshold are denoted with a white circle. Variants are grouped by chromosome. LVEDV left-ventricular end-diastolic volume, LVEDVi left-ventricular end-diastolic volume indexed for body surface area, LVSEV left-ventricular end-systolic volume, LVESVi left-ventricular end-systolic volume indexed for body surface area, LVEF left-ventricular ejection fraction, FDR false discovery rate.

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