Table 1 Results from logistic regression of the response to the question “How much, if at all, do the symptoms you have had in the last 7 days reduce your/their ability to carry out day-to-day activities?” as a function of BA.2 / BA.1 infection, age group, sex, booster vaccine received (y/n), weeks since most recent vaccine, prior COVID-19 (28 days or more before testing), weeks since symptom onset, and calendar time (since 1 Jan 2021) among 5,637 double- or triple-vaccinated swab-positive individuals with either BA.2 or BA.1 infection

From: Variant-specific symptoms of COVID-19 in a study of 1,542,510 adults in England

Variable

Category

Crude model

Plus age

Plus sex

Plus boosted

Plus weeks since vaccination

Plus prior COVID-19

Plus weeks since symptom onset

Plus calendar time (weeks)

Omicron variant

BA.1 [ref]

–

–

–

–

–

–

–

–

 

BA.2

1.86 (1.59,2.18)

1.93 (1.64,2.28)

1.94 (1.64,2.29)

1.97 (1.66,2.33)

1.91 (1.58,2.29)

1.92 (1.59,2.30)

1.70 (1.40,2.06)

1.54 (1.16,2.06)

Age

18–24 [ref]

 

–

–

–

–

–

–

–

 

25–34

 

1.22 (0.80,1.84)

1.26 (0.83,1.91)

1.26 (0.83,1.92)

1.26 (0.83,1.91)

1.27 (0.83,1.93)

1.13 (0.73,1.74)

1.13 (0.74,1.75)

 

35–44

 

1.64 (1.09,2.46)

1.70 (1.14,2.56)

1.73 (1.15,2.60)

1.71 (1.14,2.57)

1.72 (1.14,2.58)

1.63 (1.07,2.49)

1.65 (1.08,2.51)

 

45–54

 

2.07 (1.39,3.10)

2.19 (1.47,3.29)

2.25 (1.49,3.38)

2.21 (1.47,3.33)

2.20 (1.46,3.32)

2.09 (1.37,3.19)

2.12 (1.39,3.25)

 

55–64

 

2.12 (1.42,3.16)

2.30 (1.54,3.43)

2.36 (1.57,3.55)

2.31 (1.54,3.48)

2.32 (1.54,3.48)

2.24 (1.47,3.41)

2.28 (1.49,3.49)

 

65–74

 

1.24 (0.81,1.88)

1.39 (0.91,2.11)

1.43 (0.93,2.19)

1.39 (0.90,2.14)

1.37 (0.89,2.11)

1.33 (0.85,2.08)

1.36 (0.86,2.13)

Sex

Female [ref]

  

–

–

–

–

–

–

 

Male

  

0.57 (0.48,0.67)

0.57 (0.48,0.68)

0.57 (0.48,0.68)

0.57 (0.48,0.68)

0.62 (0.52,0.73)

0.62 (0.52,0.73)

Boosted (Yes)

No [ref]

   

–

–

–

–

–

 

Yes

   

0.90 (0.71,1.15)

0.97 (0.72,1.31)

0.96 (0.71,1.29)

0.92 (0.67,1.27)

0.88 (0.62,1.24)

Weeks since last vaccination

     

1.00 (0.99,1.01)

1.00 (0.99,1.01)

1.01 (0.99,1.02)

1.00 (0.99,1.02)

Prior COVID-19

(28+ days ago)

No [ref]

     

–

–

–

 

Yes

     

0.64 (0.47,0.87)

0.92 (0.65,1.30)

0.92 (0.65,1.29)

Weeks since symptom onset

       

0.81 (0.66,0.98)

0.81 (0.67,0.98)

Calendar time (weeks since 1 Jan)

        

1.02 (0.98,1.05)

  1. Each column shows the addition of one covariate to the model. Odds ratios and 95% confidence intervals are shown. BA.2 infection (vs BA.1) is associated with increased risk of reduced ability to carry out day-to-day activities. This effect is robust to adjustment. Vaccine booster status was not associated with a change in ability to carry out daily activities.
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