Fig. 2: Correlation between protein expression levels and somatic alterations. | Nature Communications

Fig. 2: Correlation between protein expression levels and somatic alterations.

From: Proteo-genomic characterization of virus-associated liver cancers reveals potential subtypes and therapeutic targets

Fig. 2

A, B Local and distant effects of somatic copy number alterations on gene expression levels in tumor. Correlation of CNA with A mRNA expression levels and B protein expression levels. The horizontal axis is the genomic coordinates of CNAs. The vertical axis represents the genomic coordinates of 209 genes, which were identical between mRNA and protein analysis. Spearman’s correlation between copy number signals and expression levels were computed. Significant correlations (FDR < 0.05) were depicted either red for positive correlations or blue for negative correlations. Bottom panel shows the number of significant correlations for each CNA locus. C, D Effects of somatic driver alterations on expression levels of their protein product. Tumors were sorted by protein expression level of C CTNNB1 and D TP53. The p-values were computed by two-sided Wilcoxon rank sum test comparing protein expression levels between wild-type and altered tumors. Source data are provided as a Source Data file.

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