Fig. 2: The hepatic TRβ is required for the regulatory effect of T3 on glucose metabolism. | Nature Communications

Fig. 2: The hepatic TRβ is required for the regulatory effect of T3 on glucose metabolism.

From: Hepatic thyroid hormone signalling modulates glucose homeostasis through the regulation of GLP-1 production via bile acid-mediated FXR antagonism

Fig. 2

a Relative Gcg mRNA levels in the ileum of Floxed and LTRβKO mice treated with PBS or T3 for 5 days as indicated (n = 4). b–d Plasma active GLP-1 (b, n = 5), plasma insulin (c, n = 5), and blood glucose levels (d, n = 6) in Floxed and LTRβKO mice treated with PBS or T3 for 5 days as indicated. e oGTT for Floxed and LTRβKO mice treated with PBS or T3 for 5 days and the AUC for oGTT (right) (n = 6). f Representative IF staining of ileal GLP-1 (green) and DAPI staining (blue) in Floxed and LTRβKO mice receiving 5 days of T3 injection. oGTT, oral GTT. Means ± SEM are shown. P values were calculated by two-tailed unpaired Student’s t test. ns not significant. Source data are provided as a Source Data file.

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