Fig. 5: TH potentiates the production of non-12α-OH FXR-antagonistic BAs. | Nature Communications

Fig. 5: TH potentiates the production of non-12α-OH FXR-antagonistic BAs.

From: Hepatic thyroid hormone signalling modulates glucose homeostasis through the regulation of GLP-1 production via bile acid-mediated FXR antagonism

Fig. 5

a–c The percentage of individual BA in the gallbladder bile (a), ileum (b) and feces (c) of MMI and MMI + T3-5d mice (n = 5). d The percentage of individual BA in the ileum of Floxed and LTRβKO mice treated with PBS or T3 for 5 days (n = 5). e–g The percentage of non-12α-OH FXR-antagonistic BAs, including T(α/β)MCA, (T/G)UDCA, and (T)HDCA in the gallbladder bile (e), ileum (f) and feces (g) of MMI and MMI + T3-5d mice (n = 5). h The percentage of non-12α-OH FXR-antagonistic BAs in the ileum of Floxed and LTRβKO mice treated with PBS or T3 for 5 days (n = 5). Means ± SEM are shown. P values were calculated by two-tailed unpaired Student’s t test. ns not significant. Source data are provided as a Source Data file.

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