Fig. 8: T3 levels are associated with GLP-1 and non-12α-OH FXR-antagonistic BA levels in humans. | Nature Communications

Fig. 8: T3 levels are associated with GLP-1 and non-12α-OH FXR-antagonistic BA levels in humans.

From: Hepatic thyroid hormone signalling modulates glucose homeostasis through the regulation of GLP-1 production via bile acid-mediated FXR antagonism

Fig. 8

a, b Correlation between free T3 levels and plasma active GLP-1 levels (a) or plasma insulin levels (b) in a cohort of euthyroid human study participants (n = 30). c–f Association analysis of free T3 levels and fecal BA levels in another cohort of euthyroid human study participants (n = 19). Correlation of free T3 levels with 12α-OH/non-12α-OH ratios (c), (T)HDCA levels (d), (T/G)UDCA levels (e), and the levels of both (T)HDCA and (T/G)UDCA (f) in the feces of these human study participants. Pearson correlation and two-tailed t-test was performed for correlation analysis. Source data are provided as a Source Data file.

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