Fig. 9: Schematic diagram of the working model. | Nature Communications

Fig. 9: Schematic diagram of the working model.

From: Hepatic thyroid hormone signalling modulates glucose homeostasis through the regulation of GLP-1 production via bile acid-mediated FXR antagonism

Fig. 9

The role of hepatic TH signaling in the regulation of glucose homeostasis. In hepatocytes, activation of TRβ by T3 shapes the BA composition and increases the levels of non-12α-OH FXR-antagonistic BAs, which are shown in red, through suppressing the CYP8B1 expression. In L-cells, inactivation of FXR signaling by non-12α-OH FXR-antagonistic BAs increases the GLP-1 production, thereby potentiating insulin secretion. CHOL, cholesterol.

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